The Nissan Murano is named after the glass sculpted in the islands near Venice. The glass is known for its beauty as well as for the high-tech methods used in its production. In the Nissan Murano, this duality is most obvious in the styling. The Murano is designed to blend the look of a car and a truck. The top half of the body is sleek like a car, while the bottom half is bulky like a truck. Overall, the look is much sleeker than tall box-shaped SUVs. At first it looks a bit over the top, but most people quickly get used to it and traditional SUVs start looking boxy and dated by comparison.

Big 18-inch wheels contribute to Murano's muscular styling. Sculpted, vertical-stack projector headlights define the front corners. The highly styled rear hatchback is made of reinforced plastic because steel won't bend easily in such a complex shape. The hatch is heavy, however, and takes some effort to raise and lower. The windshield and front side windows are tinted green to deflect UV radiation; the rear side windows and backlight are darkly tinted for privacy.

As its looks suggest, the Murano is an aerodynamic machine. Details in the design help it slip quietly through the air. Airflow-improving devices include an underbody engine cover, front and rear tire deflectors, a rear spoiler, and aerodynamic mirrors. Combined with the low frontal area and roof, these enhancements increase fuel efficiency and limit wind noise at high speeds.

To finish the high-fashion look, Nissan offers 10 exterior colors (including new Brilliant Silver and Sunset Red), with four interior hues (Charcoal, Latte, Cabernet and new Hazelnut) to mix and match. The colors were chosen carefully to promote a luxury look.